%0 Journal Article
%A Ling-Ling WANG
%A Qian ZHANG
%A Xiao-Xue ZHANG
%A Xiu-Hua ZHAO
%A Yan-Jie LIU
%T Preparation and Bioavailability of Coenzyme Q10 Xylan Nanometer Suspension Agent
%D 2020
%R 10.7525/j.issn.1673-5102.2020.06.017
%J Bulletin of Botanical Research
%P 943-950
%V 40
%N 6
%X <p>A novel copolymer-supported coenzyme Q10 formed a nanometer suspension agent and increased the water solubility of CoQ10 and improved its oral bioavailability. The quercetin-Xylan（qt-xylan） copolymer coupling was used as the basis for synthesis. The single factor experiment design was adopted， and the particle size was used as the inspection condition of the single factor experiment. The factors affecting the particle size included high pressure homogenization pressure， high pressure homogenization times， copolymer concentration， mass ratio between copolymer and CoQ10， and a series of <i>in vitro</i> experiments were carried out. When the homogenization pressure was 60 MPa， the number of homogenization was 7， the copolymer concentration was 1 mg·mL<sup>-1</sup>， and the mass ratio of copolymer to CoQ10 was 1∶1， it was the best preparation process for the nanometer suspension agent， and the particle size was 166.7 nm. Under the optimum technological conditions <i>in vitro</i> dissolution experiment，the<italic/>dissolution rate of CoQ10 nanometer suspended agent coated in artificial gastric juice（SGF） and artificial intestinal juice（SIF） was 1.89 and 1.48 times that of CoQ10 active drug， respectively. The bioavailability <i>in vivo</i> experiments， rat were loaded on gastric CoQ10 and nanoparticle suspension agent respectively. Then the blood drug concentration， different time points in drug absorption and metabolism of rats were detected respectively. The load of CoQ10 nanometer suspending agent in rats blood drug concentration was significantly higher than that of CoQ10 technical， and the bioavailability of CoQ10 reversed-phased was improved 2.64 times.</p>
%U https://bbr.nefu.edu.cn/EN/10.7525/j.issn.1673-5102.2020.06.017